Add the oil, onions, carrots, celery, and garlic to the Instant Pot on sauté mode. Cook, stirring regularly, until the veggies begin to soften, about 3-4 minutes.
Add the onion powder, garlic powder, Worcestershire, beef base, pepper, and herbs; stir to combine.
Pour in the red wine and scrape up any browned bits from the bottom of the pot.
Press cancel.
Add in the broth and stew meat.
Close and lock the lid. Be sure that the pressure release valve is set to sealing.
Press manual high pressure and adjust the cooking time to 25 minutes.
Once the cooking time has finished, do a controlled quick release.
Unlock and remove the lid.
Stir in the barley.
Press sauté, and cook for 10 minutes, stirring regularly.
Press cancel, and give everything one last good stir.
Notes
Vegetables: Feel free to increase the amount of veggies if you like a veggie-heavier soup.
Red wine: If you don't want to use red wine, you can substitute more broth or stock.
Stew meat: You can cut up a chuck roast instead of using stew meat.
Quick barley: It's important to use quick barley because regularly barley won't cook in the same amount of time.